منابع مشابه
Orlistat and sibutramine beyond weight loss.
BACKGROUND AND AIM To investigate, through a meta-analysis of clinical trials, the effect of two weight-reducing drugs, such as orlistat and sibutramine, on serum lipid profiles in overweight and obese subjects, independently of weight loss. METHODS A systematic search strategy, incorporating the terms orlistat, sibutramine, fat, cholesterol, lipid profile, cardiovascular risk, was developed ...
متن کاملTaking Orlistat: Predicting Weight Loss over 6 Months
This study explored the predictors of weight loss following orlistat with a focus on both baseline variables and changes in beliefs and behaviours occurring over the course of taking the drug. Patients (n = 566) prescribed orlistat completed a questionnaire at baseline and after 6 months concerning their weight, beliefs and behaviours. By 6 months the majority had lost some weight and showed im...
متن کاملModeling and simulation of orlistat to predict weight loss and weight maintenance in obesity patients.
Orlistat is used clinically worldwide as anti-obesity drug. It is a chemically synthesized hydrogenated derivative of lipstatin and is an inhibitor of gastric and pancreatic lipases. It has been found to reduce the absorption of dietary fat in the gastrointestinal tract. Modeling and simulation based on pharmacokinetic/pharmacodynamic analysis is becoming increasingly used in the design of clin...
متن کاملP-220: A Two Purpose Use of Orlistat in Obese Women with Polycystic Ovary Syndrome: Weight Loss and Androgen Reduction
Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in young women. PCOS affects 6% and 8% of women in reproductive age. Hyperandrogenism is the hallmark of PCOS. Clinically, it is possible to observe hirsutism, acne, androgenic alopecia, and signs of virilization. Laboratory examination reveals increased androgen levels. Excessive androgen has an important r...
متن کاملReview: orlistat and sibutramine are modestly effective for weight loss at 1 year.
and commentary also appear in ACP Journal Club. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . For correspondence: Dr R Padwal, University of Alberta and Walter C. Mackenzie Health Sciences Centre, Edmonton, Alberta, Canada. rpadwal@ ualberta.ca Source of funding: no external funding. Orlistat (Orl) or sibutramine (Sib) ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 2000
ISSN: 0002-9165,1938-3207
DOI: 10.1093/ajcn/71.3.846a