Oritavancin polymethylmethacrylate (PMMA)—compressive strength testing and in vitro elution
نویسندگان
چکیده
منابع مشابه
Optimized elution of daptomycin from polymethylmethacrylate beads.
We demonstrate that xylitol can be added to polymethylmethacrylate (PMMA) bone cement to enhance the elution of daptomycin in terms of both the peak and sustained release of antibiotic. We also demonstrate that a PMMA-xylitol formulation optimized for daptomycin can be used to enhance the elution of both vancomycin and gentamicin.
متن کاملElution of metronidazole and gentamicin from polymethylmethacrylate beads.
OBJECTIVE To characterize the elution and bioactivity of metronidazole and gentamicin sulfate polymerized, individually and in combination, with polymethylmethacrylate (PMMA). STUDY DESIGN In vitro experimental study. METHODS PMMA beads containing metronidazole (3 concentrations), gentamicin sulfate, or metronidazole and gentamicin sulfate were immersed in 5 mL of phosphate-buffered saline ...
متن کاملAntimicrobial properties and elution kinetics of linezolid from polymethylmethacrylate.
Polymethylmethacrylate (PMMA) impregnated with antibiotics is widely used in the treatment of osteomyelitis and infected arthroplasties. With the emergence of resistant bacterial strains, linezolid, which is active against gram-positive bacteria and toward which resistance has been scarce, has been suggested as an alternative. In the current in vitro study, the authors sought to determine and c...
متن کاملEvaluation of in vitro serial antibiotic elution from meropenem-impregnated polymethylmethacrylate beads after ethylene oxide gas and autoclave sterilization.
OBJECTIVES To determine the elution properties of meropenem and to compare the elutions of meropenem-impregnated polymethylmethacrylate (PMMA) beads without sterilization (P-M-C) to those sterilized with steam (P-M-A) and ethylene oxide gas (P-M-EO). METHODS A commercial bead mould was used to produce four groups of beads: one group without antibiotic (negative control), and three groups of m...
متن کاملElution of gentamicin and vancomycin from polymethylmethacrylate beads and hip spacers in vivo
BACKGROUND AND PURPOSE Late infections after total hip arthroplasty are still a problem. Treatment procedures include resection arthroplasty with implantation of antibiotic-loaded beads or implantation of an antibiotic-impreganted spacer. However, little is known about antibiotic elution from bone cement beyond the first 2-3 postoperative days in humans. METHODS 17 hip spacers (80 g PMMA, 1g ...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Surgery and Research
سال: 2019
ISSN: 1749-799X
DOI: 10.1186/s13018-019-1080-6