Origin of Radiation Carcinogenesis is Chromosome Aneuploidy
نویسندگان
چکیده
منابع مشابه
The Epigenetic Origin of Aneuploidy
Theodore Boveri, eminent German pathologist, observed aneuploidy in cancer cells more than a century ago and suggested that cancer cells derived from a single progenitor cell that acquires the potential for uncontrolled continuous proliferation. Currently, it is well known that aneuploidy is observed in virtually all cancers. Gain and loss of chromosomal material in neoplastic cells is consider...
متن کاملAneuploidy precedes and segregates with chemical carcinogenesis.
A century ago, Boveri proposed that cancer is caused by aneuploidy, an abnormal balance of chromosomes, because aneuploidy correlates with cancer and because experimental aneuploidy generates "pathological" phenotypes. Half a century later, when cancers were found to be nonclonal for aneuploidy, but clonal for somatic gene mutations, this hypothesis was abandoned. As a result, aneuploidy is now...
متن کاملPaternal sex chromosome aneuploidy as a possible origin of Turner syndrome in monozygotic twins: case report.
The meiotic or mitotic origin of most cases of Turner syndrome remains unknown, due to the difficulty in detecting hidden mosaicisms and to the lack of meiotic segregation studies. We have had the opportunity to study one pair of monozygotic twins concordant for Turner syndrome of paternal origin. The paternal origin of the single X chromosome was determined by polymerase chain reaction (PCR) a...
متن کاملRisk of Radiation Carcinogenesis
Occupational radiation exposure from the space environment may increase cancer morbidity or mortality risk in astronauts. This risk may be influenced by other space fl ight factors including microgravity and e nvironmental contaminants. A Mars mission will not be fe asible unless improved shielding is developed or transit time is decreased. – Human Research Program Requirements Document, HRP-47...
متن کاملCentrosomes, chromosome instability (CIN) and aneuploidy.
Each time a cell divides its chromosome content must be equally segregated into the two daughter cells. This critical process is mediated by a complex microtubule based apparatus, the mitotic spindle. In most animal cells the centrosomes contribute to the formation and the proper function of the mitotic spindle by anchoring and nucleating microtubules and by establishing its functional bipolar ...
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ژورنال
عنوان ژورنال: Japanese Journal of Health Physics
سال: 2012
ISSN: 0367-6110,1884-7560
DOI: 10.5453/jhps.47.118