منابع مشابه
Pharmaceutical salts.
Keyphrases D Pharmaceutical salts-general pharmacy, physicochemical properties, bioavailability, pharmaceutical properties, toxicology, review J:J Salts, pharmaceutical-general pharmacy, physicochemical properties, bioavailability, pharmaceutical properties, toxicology, review J:J Physicochemical properties-dissolution, solubility, stability, and organoleptic properties of pharmaceutical salts,...
متن کاملFacile diverted synthesis of pyrrolidinyl triazoles using organotrifluoroborate: discovery of potential mPTP blockers.
This article describes the rapid and diversified synthesis of pyrrolidinyl triazoles for the discovery of mitochondrial permeability transition pore (mPTP) blockers. The 1,3-dipolar cycloaddition of ethynyl trifluoroborate with azidopyrrolidine produced a key intermediate, triazolyl trifluoroborate 4, which subsequently underwent a Suzuki-Miyaura coupling reaction to afford a series of 1,4-disu...
متن کاملOrganotrifluoroborate hydrolysis: boronic acid release mechanism and an acid-base paradox in cross-coupling.
The hydrolysis of potassium organotrifluoroborate (RBF(3)K) reagents to the corresponding boronic acids (RB(OH)(2)) has been studied in the context of their application in Suzuki-Miyaura coupling. The "slow release" strategy in such SM couplings is only viable if there is an appropriate gearing of the hydrolysis rate of the RBF(3)K reagent with the rate of catalytic turnover. In such cases, the...
متن کاملSmelling salts.
I was delving into some reference material recently, trying to track down details of early treatment of mild head injury, and I was struck by the repeated mention of smelling salts as a folk remedy for this problem. But just what are smelling salts? Do they work and can they cause injury? Although smelling salts have recently undergone a resurgence of interest by athletes as a pre-game stimulan...
متن کاملAn efficient synthesis of imidazolinium salts using vinyl sulfonium salts.
The synthesis of imidazolinium salts from the reaction of formamidines and (2-bromoethyl)diphenylsulfonium triflate is described. A variety of symmetrical and unsymmetrical imidazolinium triflate salts were synthesized in high yield in short reaction times under mild conditions. Aromatic and aliphatic N-substituents work well. The reaction is proposed to proceed via generation of a vinyl sulfon...
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ژورنال
عنوان ژورنال: Synlett
سال: 2009
ISSN: 0936-5214,1437-2096
DOI: 10.1055/s-0028-1083584