Organophosphorus poisoning: A social calamity
نویسندگان
چکیده
منابع مشابه
Organophosphorus poisoning (acute).
INTRODUCTION Acetylcholinesterase inhibition by organophosphorus pesticides or organophosphate nerve agents can cause acute parasympathetic system dysfunction, muscle weakness, seizures, coma, and respiratory failure. Prognosis depends on the dose and relative toxicity of the specific compound, as well as pharmacokinetic factors. METHODS AND OUTCOMES We conducted a systematic review and aimed...
متن کاملOrganophosphorus poisoning and anaesthesia.
Organophosphorus compounds, used as insecticides and agents of chemical warfare, are a major global cause of health problems. These irreversible inhibitors of cholinesterase produce three well-recognised clinical entities: the initial cholinergic phase, which is a medical emergency often requiring management in an intensive care unit; the intermediate syndrome, during which prolonged ventilator...
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Oximes are well known as acetylcholinesterase reactivators and are used in organophosphorus poisoning to reactivate inhibited acetylcholinesterase. Therapeutically available oximes, namely, pralidoxime (2-PAM), obidoxime, trimedoxime and Hagedorn oxime (HI-6), have no broad-spectrum activity against structurally different kinds of organophosphorus anticholinesterases. The widely used oxime, 2-P...
متن کاملCurrent review on organophosphorus poisoning
Organophosphorus (OP) compounds constitute a heterogeneous category of chemicals specifically designed for the control of pests, weeds or plant diseases. Our review article mainly focused on OP poisoning, especially with pesticides, its severity and management of toxic exposure. We developed a search strategy to find publications about OP poisoning and its management. So, we searched Science Di...
متن کاملAntioxidants in organophosphorus compounds poisoning.
Oxidative stress has recently been implicated as a factor in the mortality and morbidity induced by organophosphorus (OP) compound poisoning. An overwhelming number of research papers are based on studying at the cellular and organ level. Such studies have concluded that antioxidants can be used as an adjunct compound in the treatment of both chronic as well as acute OP poisoning. Still, the ro...
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ژورنال
عنوان ژورنال: Journal of Mahatma Gandhi Institute of Medical Sciences
سال: 2015
ISSN: 0971-9903
DOI: 10.4103/0971-9903.151736