منابع مشابه
Catalytic organometallic anticancer complexes.
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New anion hosts have been accessed using cationic organometallic fragments with sufficient kinetic stability as geometry-organizing cores, simple ditopic ligands featuring hydrogen bond donor groups, and the inert, low interacting, lipophilic BAr'(4) anion.
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The chemistry of metal cyclopropenyl complexes derived from deprotonation of cationic ruthenium vinylidene complexes is reviewed. Such a metal coordinated cyclopropenyl ligand can be used for the preparation of heterocyclic compounds. The chemical reactivity of cyclopropenyl complexes is influenced by the nature of substituents on the three-membered ring and by the nature of ancillary ligand ar...
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Organometallic complexes offer potential for design as anticancer drugs. They can act as inert scaffolds and specifically inhibit enzymes such as kinases, or as pro-drugs which undergo activation by various mechanisms. The activation of metallocenes, arene, alkyl or aryl complexes by hydrolysis, and metalor ligandbased redox reactions is discussed.
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A new metal-containing scaffold for the design of protein kinase inhibitors is introduced. Key feature is a 3-(2-pyridyl)-1,8-naphthalimide "pharmacophore chelate ligand" which is designed to form two hydrogen bonds with the hinge region of the ATP-binding site and is at the same time capable of serving as a stable bidentate ligand through C-H-activation at the 4-position of the electron-defici...
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ژورنال
عنوان ژورنال: Nature Chemistry
سال: 2016
ISSN: 1755-4330,1755-4349
DOI: 10.1038/nchem.2520