Organic Phosphates. I. Synthesis of 1, 2-Diol Cyclic Phosphates.
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چکیده
منابع مشابه
Synthesis of inositol glycan cyclic phosphates.
An efficient synthesis of tri-, tetra-, and pentasaccharide cyclic phosphates 1-5, structurally related to natural inositol phosphate glycans, is reported. The title compounds were assembled by PhSeOTf-promoted glycosylation of the known glucosamine precursor, t-butyldimethylsilyl 2-azido-3,6-di-O-benzyl-2-deoxy-beta-D-glucopyranoside (8) with protected 1-methylthio mono-, di-, and trimannoside...
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Pseudomonas putia'a oxidation of benzene affords cis-3,5-cyclohexadiene1,2diol (JJ which serves as a novel precursor for the syntheses of several natural products including (+)-pinitol, (+)-condunto1 F, D-(-)-myo-inositol 1,4,5-trisphosphate and Dmyo-inositol 1-phosphate. The versatility of this approach is further demonstrated by the preparation of other functionalised cyclitol derivatives, in...
متن کاملSynthesis of phosphonate and phostone analogues of ribose-1-phosphates
The synthesis of phosphonate analogues of ribose-1-phosphate and 5-fluoro-5-deoxyribose-1-phosphate is described. Preparations of both the alpha- and beta-phosphonate anomers are reported for the ribose and 5-fluoro-5-deoxyribose series and a synthesis of the corresponding cyclic phostones of each alpha-ribose is also reported. These compounds have been prepared as tools to probe the details of...
متن کاملEnzymatic synthesis of sialic acid 9-phosphates.
7Jourdian, G. W., and S. Roseman, Abstracts, 137th Meeting of the American Chemical Society, 1960, p. 47C. 8 Byrne, W. L., and H. A. Lardy, Biochim. et Biophys. Acta, 14, 495-601 (1954). 9 Dische, Z., and Borenfreund, E., J. Biol. Chem., 180, 1297-1300 (1949). 10 Ballou, C. E., Arch. Biochem. & Biophys., 78, 328-333 (1958). 11 Warren, L., and H. Felsenfeld, Biochem. Biophys. Res. Comm., 4, 232-...
متن کاملBiologic activity of cyclic and caged phosphates: a review.
The recognition in the early 1960s by Morifusa Eto that tri-o-cresyl phosphate (TOCP) is hydroxylated by the cytochrome P450 system to an intermediate that spontaneously cyclizes to a neurotoxic phosphate (saligenin phosphate ester) ignited the interest in this group of compounds. Only the ortho isomer can cyclize and clinically cause Organo Phosphate Induced Delayed Neurotoxicity (OPIDN); the ...
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ژورنال
عنوان ژورنال: Pharmaceutical Bulletin
سال: 1957
ISSN: 0369-9471,1881-1345
DOI: 10.1248/cpb1953.5.121