Organic Light‐Emitting Diodes as an Innovative Approach for Treating Cutaneous Leishmaniasis

Abstract Antimicrobial photodynamic therapy (APDT) has been studied as a noninvasive for treating cutaneous leishmaniasis to overcome challenges with current treatment, such toxicity, resistance, and need in‐patient hospital treatment. Organic light‐emitting diodes (OLEDs) have emerged an attractive technology that can provide wearable materials are conformable human skin. This makes OLEDs ideal candidates APDT by light‐bandages ambulatory care. In this work, suitable successfully developed match the absorbance of three photosensitizers: methylene blue, new 1,9‐dimethyl‐methylene blue inactivate two Leishmania species in vitro: major amazonensis . Parasites treated either LED (20 mW cm −2 ) or OLED (6.5 at increasing photosensitizer concentrations radiant exposure 50 J 1,9‐Dimethyl‐methylene is most potent photosensitizer, killing both strains nanomolar concentrations. The effect different intensities from (0.7, 1.5, 6.5 also explored it shown effective occurs even very low intensity. These findings demonstrate great potential approach treatment APDT.