Orexins (hypocretins): The intersection between homeostatic and hedonic feeding

Orexins are hypothalamic neuropeptides originally discovered to play a role in the regulation of feeding behaviour. The broad connections orexin neurons mesocorticolimbic circuitry suggest they may mediating reward-related behaviour beyond homeostatic feeding. Here, we review variety eating-related behaviour, with focus on reward and motivation, neural circuits driving these effects. One emerging finding is involvement orexins hedonic appetitive towards palatable food, addition their This discusses brain possible mechanisms underlying behaviours. Overall, there marked bias literature studies involving male subjects. As such, future work needs be done involve female In summary, an important motivation for high salient rewards such as highly food serve intersection between