Oral tolerance to food protein

Specific oral tolerance induction in food allergy.

Specific oral tolerance in food allergy can be induced by oral administration of the offending food, starting with very low dosages, gradually increasing the daily dosage up to an amount equivalent to a usually relevant dose for daily intake, followed up by a daily maintenance dose. Unfortunately, the body of scientific evidence concerning specific oral tolerance induction (SOTI) is still rathe...

Specific oral tolerance induction for food. A systematic review.

BACKGROUND Specific oral tolerance induction (SOTI) is a new therapeutic approach in the treatment of persistent food allergy. OBJECTIVE The purpose of this article is to systematically review the literature in order to identify, appraise, and synthesize the evidence about SOTI efficacy and safety. METHODS A comprehensive search for citations was conducted on May 2, 2009 using MEDLINE via P...

Does IgE-mediated mast cell activation reduce oral tolerance to food antigens?

Mast cell activation in response to food allergens can result in symptoms such as anaphylaxis. It is unclear how this activation impacts on the immune response to other foods that are present. The objective of this study was to investigate the role of immunoglobulin E (IgE)-mediated mast cell activation in the regulation of oral tolerance to a food antigen using a mouse model. Oral tolerance to...

Immunological changes related to oral tolerance

Background The default response to protein antigens in the intestine is the induction of systemic and local hyporesponsiveness (OT). There is increasing interest in the role of dietary manipulation and probiotics in the development and prevention of allergic and other diseases. Little is known how the environment and nutritional factors modulate systemic and local immune responses. This present...

Tolerance Lymphocytes Are Refractory to Oral Kinetic Analysis of Oral Tolerance: Memory