Oral tolerance therapy in type 1 diabetes mellitus
نویسندگان
چکیده
منابع مشابه
Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus.
Oxidative stress decreases the bioavailability of endothelium-derived nitric oxide in diabetic patients. We investigated whether impaired endothelium-dependent vasodilation (EDV) in diabetes can be improved by long-term administration of oral antioxidants. Forty-nine diabetic subjects [26 Type 1 (T1) and 23 Type 2 (T2)] and 45 matched healthy control subjects were randomized to receive oral vit...
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Diabetes mellitus is a chronic disease that is growing in prevalence worldwide. Pharmacologic therapy is often necessary to achieve optimal glycemic control in the management of diabetes. Orally administered antihyperglycemic agents (OHAs) can be used either alone or in combination with other OHAs or insulin. The number of available OHAs has increased significantly in the last decade, which tra...
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Tolerogenic strategies that specifically target diabetogenic immune cells in the absence of complications of immunosuppression are the desired treatment for the prevention or even reversal of Type 1 diabetes (T1D). Antigen (Ag)-based therapies must not only suppress disease-initiating diabetogenic T cells that are already activated, but, more importantly, prevent activation of naive auto-Ag-spe...
متن کاملAssessment of Oral Therapy in Diabetes Mellitus.
EARLIER trials at Whittington Hospital confirmed the hypoglycaemic effects of tolbutamide (Wolff, Stewart, Crowley and Bloom, 1956), phenformin (Hall, Crowley and Bloom, 1958) and chlorpropamide (Granville-Grossman, Crawford, Crowley and Bloom, 1959). Since the inception of oral therapy, more than 400 diabetics at this hospital have been successfully treated with these agents for more than thre...
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ژورنال
عنوان ژورنال: Chinese Medical Journal
سال: 2020
ISSN: 0366-6999,2542-5641
DOI: 10.1097/cm9.0000000000001130