Oral Presentation No. 121 Aortic stiffness descriptors by cardiac magnetic resonance are correlated with mechanical testing of ex-vivo aortic aneurysms specimens

Abstract Background Aortic stiffness independently predicts mayor adverse cardiovascular events and mortality in the general population. Cardiovascular magnetic resonance (CMR) permits assessment of a number parameters theoretically linked to aortic stiffness, such as distensibility (AD), pulse wave velocity (PWV) proximal aorta longitudinal strain. However, no previous study validates these descriptors wall against ex-vivo mechanical testing. Materials methods Ascending (AAo) specimens were collected from 20 patients undergoing AAo replacement for aneurysms. Patients underwent CMR protocol days leading surgery, including 4D flow CMR. Two 15×5 mm (one oriented circumferential other direction) extracted during later tested controlling extension force. Elongation was measured by laser video extensometer tangent stress-strain curve at diastolic pressure extracted. PWV Eh product (E being Young modulus h thickness) while AD quantified cine images. Results conclusions Marked correlations found between elastic (R = ?0.502), PWV(R 0.652) 0.602). Similarly, strong correlation identified strain modulus(R ?0.513). In conclusion, are positively related show negative relationships. Thus, biomarkers reliable expression stiffness. Funding PI17/00381,SEC/FEC-INV-CLI20/015,LCF/BQ/PR22/11920008.