Oral lyophilizates obtained using aggressive drying conditions: Effect of excipients
نویسندگان
چکیده
Orodispersible drug formulations are a current trend in the pharmaceutical industry, mostly intended for pediatric and geriatric patients. Oral lyophilizates solid forms, either to be placed mouth or dispersed (or dissolved) water before administration. The correct excipient composition is prerequisite provide with appropriate visual appearance disintegration time. Typically, they composed of binders, such as gelatin polyvinylpyrrolidone, fillers sucrose, mannitol, sorbitol, taste modifiers, colorants, sweeteners, preservatives. main purpose this study was determine optimal scaffold ensure proper that have undergone aggressive drying conditions time less than 3 min. In addition mannitol gelatin, most frequently used PVP K25, K90, glycine, croscarmellose, hydrolyzed were investigated. results obtained revealed only too long, replacement K25 led friable cracked lyophilizates. Considering appearance, mixture (1:2:5) formed from liquid 6% (w/w) excipients determined suitable. As binder, expresses more characteristics relating K90. Addition croscarmellose provided shorter time, whereas glycine had positive effect on elegant lyophilizate cakes. Hydrolyzed introduced aim obtaining an even at same acceptable This achieved by lyophilization solutions 15% gelatin:PVP K25:glycine/croscarmellose:mannitol ratio 4:2:0.5:4.5. Such show highest potential incorporation poorly soluble low-dose drugs.
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ژورنال
عنوان ژورنال: Journal of Drug Delivery Science and Technology
سال: 2023
ISSN: ['1773-2247', '2588-8943']
DOI: https://doi.org/10.1016/j.jddst.2023.104379