Oral iloprost treatment in patients with Raynaud's phenomenon secondary to systemic sclerosis: A multicenter, placebo‐controlled, double‐blind study
نویسندگان
چکیده
منابع مشابه
Oral iloprost in Raynaud's phenomenon secondary to systemic sclerosis: a multicentre, placebo-controlled, dose-comparison study.
OBJECTIVE To identify the optimal dose of oral iloprost on the basis of efficacy and tolerability in patients with Raynaud's phenomenon secondary to systemic sclerosis. DESIGN Multicentre, randomized, parallel-group comparison of two different doses of oral iloprost and placebo. SETTING European university hospitals. PATIENTS A total of 103 patients with Raynaud's phenomenon secondary to ...
متن کاملComparison of intravenous infusions of iloprost and oral nifedipine in treatment of Raynaud's phenomenon in patients with systemic sclerosis: a double blind randomised study.
OBJECTIVE To compare the long term effects of short term intravenous infusions of iloprost with those of oral nifedipine in patients with Raynaud's phenomenon associated with systemic sclerosis. DESIGN Double blind, placebo controlled, randomised group comparison. SETTING Dermatology outpatient clinic. PATIENTS Twenty three patients with Raynaud's phenomenon associated with well documente...
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R aynaud’s phenomenon (RP) with or without digital ulcer formation is a significant cause of morbidity for patients with systemic sclerosis (SSc, scleroderma). Lichtenstein reported oral sildenafil as a treatment of RP for patients with SSc, systemic lupus erythematosus, and idiopathic RP. His report included 10 patients from his community office practice given sildenafil, 50 mg once orally at ...
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Iloprost, a stable prostacyclin analogue, was given by intravenous infusion to 29 patients with severe Raynaud's phenomenon, 26 of whom had systemic sclerosis (SS), and compared with placebo infusion in a double blind crossover trial. Iloprost significantly lessened the number and the severity of attacks compared with placebo. Nine patients expressed a preference for effectiveness of treatment,...
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Patients with systemic sclerosis frequently have Raynaud's phenomenon and digital ischemic ulcers. Iloprost, a synthetic prostacyclin analogue, may be effective in these cases. Searching in Epistemonikos database, which is maintained by screening 20 databases, we identified three systematic reviews including seven randomized trials. We combined the evidence using meta-analysis and generated a s...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1998
ISSN: 0004-3591,1529-0131
DOI: 10.1002/1529-0131(199804)41:4<670::aid-art14>3.3.co;2-9