Oral fluid cocaine and benzoylecgonine concentrations following controlled intravenous cocaine administration
نویسندگان
چکیده
منابع مشابه
Simultaneous pharmacokinetic modeling of cocaine and its metabolites, norcocaine and benzoylecgonine, after intravenous and oral administration in rats.
To accurately assess the mechanism of involvement of the active metabolite norcocaine in the effects of oral cocaine, it is essential to determine the rate and extent of the formation of norcocaine. Although this study was designed specifically for this aim, it was also of interest to characterize the metabolite kinetics of benzoylecgonine for comparative purpose. We first characterized the pha...
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Hair testing for the determination of drug exposure has many useful applications. Drug incorporated into hair can be found for extended periods following drug exposure. There are few controlled drug administration studies investigating drug distribution into human hair. Ten volunteers participated in a 10-week controlled cocaine and codeine administration study while residing in the secure rese...
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ژورنال
عنوان ژورنال: Forensic Science International
سال: 2016
ISSN: 0379-0738
DOI: 10.1016/j.forsciint.2016.01.013