Oral Artesunate Dose-Response Relationship in Acute Falciparum Malaria
نویسندگان
چکیده
منابع مشابه
Oral artesunate dose-response relationship in acute falciparum malaria.
The combination of an oral artemisinin derivative (usually artesunate) and mefloquine has become standard treatment for multidrug-resistant falciparum malaria in several parts of Southeast Asia. The doses of artesunate used in monotherapy and combination treatment have largely been derived empirically. In order to characterize the in vivo dose-response relationship for artesunate and thus ratio...
متن کاملAntimalarial bioavailability and disposition of artesunate in acute falciparum malaria.
The pharmacokinetic properties of oral and intravenous artesunate (2 mg/kg of body weight) were studied in 19 adult patients with acute uncomplicated Plasmodium falciparum malaria by using a randomized crossover design. A sensitive bioassay was used to measure the antimalarial activity in plasma which results from artesunate and its principal metabolite, dihydroartemisinin. The oral study was r...
متن کاملComparison of oral artesunate and quinine plus tetracycline in acute uncomplicated falciparum malaria.
In Thailand Plasmodium falciparum malaria is highly resistant to available antimalarials. Investigations on the efficacy of existing antimalarials and of alternative drugs are urgently needed. Artesunate has been shown to be effective against falciparum malaria, but is associated with a high recrudescence rate. We have carried out a comparative clinical trial of the standard regimen of quinine ...
متن کاملArtesunate Dosing in Severe Falciparum Malaria
TO THE EDITOR—In the past 6 years the largest ever randomized controlled trials in severe falciparum malaria have been reported [1, 2]. Compared with quinine, parenteral artesunate reduced mortality by 22.5% (from 10.9% to 8.5%) in African children (N = 5425) and by 35% (from 22% to 15%) in Southeast Asian patients (N = 1461, of whom 202 were children). The artesunate dose evaluated in the AQUA...
متن کاملEffect of High-Dose or Split-Dose Artesunate on Parasite Clearance in Artemisinin-Resistant Falciparum Malaria
BACKGROUND The emergence of Plasmodium falciparum resistance to artemisinins on the Cambodian and Myanmar-Thai borders poses severe threats to malaria control. We investigated whether increasing or splitting the dose of the short-half-life drug artesunate improves parasite clearance in falciparum malaria in the 2 regions. METHODS In Pailin, western Cambodia (from 2008 to 2010), and Wang Pha, ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2002
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.46.3.778-782.2002