Optimizing Chemotherapy Dose and Schedule by Norton-Simon Mathematical Modeling

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Mathematical Modeling and Lyapunov-Based Drug Administration in Cancer Chemotherapy

In this paper a new mathematical model is developed for the dynamics between tumor cells, normal cells, immune cells, chemotherapy drug concentration and drug toxicity. Then, the theorem of Lyapunov stability is applied to design treatment strategies for drug protocols that ensure a desired rate of tumor cell kill and push the system to the area with smaller tumor cells. Using of this theorem a...

متن کامل

Optimizing the dose and schedule of darbepoetin alfa in patients with chemotherapy-induced anemia.

Chemotherapy-induced anemia is common in patients who have cancer. Erythropoiesis-stimulating proteins such as epoetin alfa (Procrit) and darbepoetin alfa (Aranesp) have been shown to improve hematologic and clinical outcomes in these patients. Darbepoetin alfa has a longer serum half-life than epoetin alfa, making less frequent administration possible and offering the possibility of synchroniz...

متن کامل

Forecasting Final Schedule and Cost of Projects by Using Statistical and Mathematical Method

Earned value management (EVM) has prepared some methods to forecast final costs of projects. These methods were not developed since the start of formation and were gradually completed, of course with one exception that is its authenticity, they are still remained unchanged. At the present time EVM guide does not apply from schedule indices to forecast schedule for completion of project and ...

متن کامل

Periodic Chemotherapy Dose Schedule Optimization Using Genetic Algorithm

This paper presents a design method for optimal cancer chemotherapy schedules using genetic algorithm (GA). The main objective of chemotherapy is to reduce the number of cancer cells or eradicate completely, if possible, after a predefined time with minimum toxic side effects which is difficult to achieve using conventional clinical methods due to narrow therapeutic indices of chemotherapy drug...

متن کامل

Tumor growth instability and its implications for chemotherapy.

Optimal delivery of chemotherapy intensity is dependent on host- and tumor-specific characteristics. In this article, the chemotherapy late intensity schedule is revised to account for tumor growth instability, where a small tumor cell fraction emerges that exhibits a higher proliferation rate than the parent strain. Modeling this instability as simplified two-population dynamics, we find that:...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Breast Disease

سال: 2010

ISSN: 1558-1551,0888-6008

DOI: 10.3233/bd-2009-0290