Optimizing C2C12 myoblast differentiation using polycaprolactone–polypyrrole copolymer scaffolds
نویسندگان
چکیده
منابع مشابه
Proteomics-based investigation in C2C12 myoblast differentiation
Skeletal muscle cell differentiation is a multistage process extensively studied over the years. Even if great improvements have been achieved in defining biological process underlying myogenesis, many molecular mechanisms need still to be clarified. To further highlight this process, we studied cells at undifferentiated, intermediate and highly differentiated stages, and we analyzed, for each ...
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Mouse-derived C2C12 myoblasts serve as an experimentally tractable model system for investigating the molecular basis of skeletal muscle cell specification and development. To examine the biochemical adaptations associated with myocyte formation comprehensively, we used large scale gel-free tandem mass spectrometry to monitor global proteome alterations throughout a time course analysis of the ...
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Myostatin, a member of the transforming growth factor-β (TGF-β) superfamily, is expressed in developing and adult skeletal muscle and negatively regulates skeletal muscle growth. Recently, myostatin has been found to be expressed in tendons and increases tendon fibroblast proliferation and the expression of tenocyte markers. C2C12 is a mouse myoblast cell line, which has the ability to transdif...
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ژورنال
عنوان ژورنال: Journal of Biomedical Materials Research Part A
سال: 2018
ISSN: 1549-3296,1552-4965
DOI: 10.1002/jbm.a.36556