منابع مشابه
Reliability of in vivo glutamate detection with MRS at 3T
R. L. O'Gorman, J. Noble, J. M. Stone, D. J. Lythgoe, M. A. McLean, F. A. Chowdhury, P. K. McGuire, M. P. Richardson, and G. J. Barker Neuroradiology, King's College Hospital, London, United Kingdom, MR-Zentrum, University Children's Hospital, Zurich, Switzerland, Medical Engineering and Physics, King's College Hospital, London, United Kingdom, Psychological Medicine and Psychiatry, Institute o...
متن کاملDetection of Resolved Glutamate and/or Glutamine Using Optimized STEAM at 3T – A Verification Study by Phantom Experiments
designed in [2] for unobstructed Glu and Gln detection with chosen (TE, TM) regions in white boxes for phantom experiments. Fig. 2. In vitro STEAM spectra of Glu and Gln acquired at (72ms, 06 ms) and (84 ms, 58 ms) at 3T and multiplied with a filter to render them representative of typical in vivo line widths. Fig. 3. In vivo STEAM spectra acquired from a voxel including the ACC of a healthy vo...
متن کاملNeurotransmitter profiling at 3T using GABA optimized PRESS sequence
Introduction: GABA is the major inhibitory neurotransmitter in mammalian brain and GABAergic alterations have been implicated in several psychiatric and neurological disorders. GABA was also proposed to underlie DFM modulation (1). Because of this growing interest in understanding physiology and pathophaysiology of cerebral GABA homeostasis, there is a need for robust measurement of in vivo GAB...
متن کاملOptimized saturation pulse rrains for SASHA T1 mapping at 3T
Background SASHA and MOLLI T1 mapping sequences can have errors in calculated T1 values when their magnetization preparation pulses do not fully saturate/invert magnetization [1,2]. The commonly used 90°-90°-90° saturation pulse train [3] has poor performance at 3T due to large B1 field inhomogeneities. We propose that a new hard RF pulse train with numerically optimized flip angles [4] will of...
متن کاملQuantification of Glutamate and Glutamine using CT-PRESS at 3T
Introduction Glutamate (Glu) and glutamine (Gln) are two major neurochemicals in the central nervous system. Quantifying Glu and Gln in vivo using magnetic resonance spectroscopy (MRS) has been of particular interest to basic science for understanding the Glu/Gln component of the Krebs cycle and its alteration by neuropsychiatric disorders such as Alzheimer’s disease, epilepsy and alcoholism. H...
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ژورنال
عنوان ژورنال: Journal of Magnetic Resonance Imaging
سال: 2009
ISSN: 1053-1807,1522-2586
DOI: 10.1002/jmri.21936