Optimized and validated spectrophotometric methods for the determination of hydroxyzine hydrochloride in pharmaceuticals and urine using iodine and picric acid
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Optimized and validated spectrophotometric methods for the determination of hydroxyzine hydrochloride in pharmaceuticals and urine using iodine and picric acid
Two simple, rapid, cost-effective and sensitive spectrophotometric procedures are proposed for the determination of hydroxyzine dihydrochloride (HDH) in pharmaceuticals and in spiked human urine. The methods are based on the charge transfer complexation reaction of the drug with either iodine (I2) as a σ-acceptor (method A) in dichloromethane or picric acid (PA) as a π-acceptor (method B) in ch...
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ژورنال
عنوان ژورنال: Journal of the Serbian Chemical Society
سال: 2011
ISSN: 0352-5139,1820-7421
DOI: 10.2298/jsc101007138r