Optimization of radiation controlled gene expression by adenoviral vectors in vitro
نویسندگان
چکیده
منابع مشابه
Inhibition of repair of radiation-induced DNA damage enhances gene expression from replication-defective adenoviral vectors.
Radiation has been shown to up-regulate gene expression from adenoviral vectors in previous studies. In the current study, we show that radiation-induced dsDNA breaks and subsequent signaling through the mitogen-activated protein kinase (MAPK) pathway are responsible, at least in part, for this enhancement of transgene expression both in vitro and in vivo. Inhibitors of ataxia-telangiectasia-mu...
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Gene expression-based imaging coupled to gene therapy will permit the prediction of therapeutic outcome. A significant challenge for successful gene therapy is to achieve a high-level of specific gene expression; however, tissue-specific promoters are weak. We postulate that if the weak activity of tissue-specific promoters can be amplified to the levels of strong viral promoters, which have be...
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ژورنال
عنوان ژورنال: Cancer Gene Therapy
سال: 2005
ISSN: 0929-1903,1476-5500
DOI: 10.1038/sj.cgt.7700829