Optimization of cytarabine (ARA-C) therapy for acute myeloid leukemia

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Optimization of cytarabine (ARA-C) therapy for acute myeloid leukemia

Cytarabine (cytosine arabinoside) is one of the most effective drugs for the treatment of acute myeloid leukemia. The standard dose of cytarabine used to treat this leukemia is 100 mg per square meter. In an attempt to improve the effectiveness of cytarabine against acute myeloid leukemia, a high-dose treatment (3,000 mg per square meter) was introduced into therapy. The side effects of high-do...

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Pancreatitis during therapy of acute myeloid leukemia: cytarabine related?

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High-dose cytarabine induction for acute myeloid leukemia.

In a recent article, Bishop et al’ state that high-dose cytarabine has not previously been used as induction for untreated acute myeloid leukemia (AML). In fact, high-dose cytarabine has been used by itself: with am~acrine,~ and with daunorubicin4 in this role. Additionally, doses of cytarabine significantly above those considered standard had previously been used by other groups for initial in...

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A randomized comparison of modified intermediate-dose Ara-C versus high-dose ara-c in post-remission therapy for acute myeloid leukemia.

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Facts about FCE (fludarabine, cytarabine, etoposide) in acute myeloid leukemia.

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ژورنال

عنوان ژورنال: Experimental Hematology & Oncology

سال: 2013

ISSN: 2162-3619

DOI: 10.1186/2162-3619-2-20