Optimization of a drug transporter probe cocktail: potential screening tool for transporter-mediated drug-drug interactions
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چکیده
منابع مشابه
Transporter-Mediated Drug–Drug Interactions with Oral Antidiabetic Drugs
Uptake transporters (e.g., members of the SLC superfamily of solute carriers) and export proteins (e.g., members of the ABC transporter superfamily) are important determinants for the pharmacokinetics of drugs. Alterations of drug transport due to concomitantly administered drugs that interfere with drug transport may alter the kinetics of drug substrates. In vitro and in vivo studies indicate ...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2018
ISSN: 0306-5251
DOI: 10.1111/bcp.13609