OPTIMIZATION AND PHYSICAL STABILITY OF KEMBANG BULAN (Tithonia diversifolia [A.Gray] EXTRACT CREAM FORMULA

Based on recent studies, the ethanolic extract of Kembang Bulan leaves (Tithonia diversifolia[A.Gray]) has an anti-keloid effect. This study aims to determine optimum formula for cream preparations with paraffinum liquidum, cetyl alcohol, and stearyl alcohol. Inappropriate comparison additional ingredients results in physical properties preparation becoming unstable during storage. The was obtained from optimization using Simplex Lattice Design (SLD) by software Expert version 10.0. parameters measured were viscosity, pH, spreadability, adhesive ability, accelerated (centrifugation). consists 19.11% b / b; Cetyl alcohol a level 2.01% 1.49% viscosity 134.35 dPa.s, spread 5.78 cm, pH 6.243, ability 13.61 seconds. base produced is milky white, 143.99 5.7 6.305, adhesion 14.57 There significant difference experimental prediction. However, there no spreadability response. have stability except its spreadability. During 4 weeks storage, both creams are relatively stable. stable after centrifugation.