OPTIMASI HYDROXYPROPYL METHYL CELLULOSE K15M DAN NATRIUM CARBOXYMETHYL CELLULOSE SEDIAAN BUCCAL FILM

ABSTRACT
 In 2020 the number of cases Dengue Hemorrhagic Fever in Indonesia until 49th week reached 95,893 and caused death around 661 people. This study aims to obtain bestformula buccal film by optimizing concentration HPMC K15M Na. CMC evaluation characterization ofpreparations with 3 variations ratios against formulas on Na polymer excipients. include F1 0.67% : 0.33% ; F2 0.65% 0.5% F3 0.67%. Research methods carried out bylaboratory experiments vitro optimization manufacture film. The results obtained three met standard formula being best based viscosity 578.667±35.85, pH wet mixture 6.24±0.08, folding resistance >300, surface 6.85±0.026, uniformityweight 6 mg±0.22,thickness uniformity 0.03±0.009 which resulted infilm a clear white, smooth dry surface. Thus, it was concluded that from Na.CMC, found requirements smallest deviation value.
 
 Keywords Fever, K15M, Buccal Film