Optimal Rectification without Forward-Current Suppression by Biological Molecular Motor

نویسندگان

چکیده

We experimentally showed that biological molecular motor F$_1$-ATPase (F$_1$) implements an optimal rectification mechanism. F$_1$ hardly suppresses adenosine triphosphate (ATP) synthesis, which is the F$_1$'s physiological role while inhibiting unfavorable hydrolysis of ATP. This a high contrast to simple ratchet model, where inhibition backward current inevitably accompanied by suppression forward current. The detailed analysis single-molecule trajectories demonstrated novel but mechanism with parallel landscapes and asymmetric transition rates.

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ژورنال

عنوان ژورنال: Physical Review Letters

سال: 2021

ISSN: ['1079-7114', '0031-9007', '1092-0145']

DOI: https://doi.org/10.1103/physrevlett.126.208101