Optimal placement of electrodes in an electroporation process
نویسندگان
چکیده
منابع مشابه
Instrumentation and electrodes for in vivo electroporation.
Electroporation (EP) of drugs and genes into cells in vitro became a standard procedure in molecular biology laboratories in the last decade. Numerous protocols aid the researcher in selecting appropriate procedures; commercial instrumentation is readily available and discussed (1). The more recent transition to applying EP to living tissue poses a new set of requirements and few practical guid...
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Electroporation in cancer therapy in which elongated micron-sized conductors are used to enhance an externally applied electric field is investigated. Such field enhancement was previously used in carbon and boron nitride nanotube electropermeabilization. It is envisaged that the micro-conductors would be injected together with therapeutic drugs into tumorous regions, and a pulsed or alternatin...
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in this work, designs for planar, interdigitated circular electrode structures for cell membrane permeabilization procedures are analysed using finite element method analysis. The generated electric field intensity, homogeneity and the Joule heating are evaluated. The optimal electrode configuration for successful transfection procedures is investigated. Based on the simulation results, an opti...
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ژورنال
عنوان ژورنال: ESAIM: Proceedings
سال: 2010
ISSN: 1270-900X
DOI: 10.1051/proc/2010004