Optimal asthma control, starting with high doses of inhaled budesonide
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چکیده
منابع مشابه
Optimal asthma control, starting with high doses of inhaled budesonide.
The aim of this study was to determine whether outcomes in poorly controlled asthma can be further improved with a starting dose of inhaled budesonide higher than that recommended in international guidelines. The study had a parallel-group design and included 61 subjects with poorly controlled asthma, randomized to receive 3,200 microg or 1,600 microg budesonide daily by Turbuhaler for 8 weeks ...
متن کاملA comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma.
BACKGROUND Inhaled glucosteroids and oral theophylline are widely used to treat asthma. We compared the benefits of adding theophylline to inhaled glucosteroid with those of doubling the dose of inhaled glucosteroid in patients with persistent symptoms despite the use of inhaled glucosteroid. METHODS In a double-blind, placebo-controlled trial, we randomly assigned 62 patients to receive eith...
متن کاملRandomised controlled trial of montelukast plus inhaled budesonide versus double dose inhaled budesonide in adult patients with asthma.
BACKGROUND Inhaled corticosteroids (ICS) affect many inflammatory pathways in asthma but have little impact on cysteinyl leukotrienes. This may partly explain persistent airway inflammation during chronic ICS treatment and failure to achieve adequate asthma control in some patients. This double blind, randomised, parallel group, non-inferiority, multicentre 16 week study compared the clinical b...
متن کاملEffect of differing doses of inhaled budesonide on markers of airway inflammation in patients with mild asthma.
BACKGROUND It is desirable to prescribe the minimal effective dose of inhaled steroids to control asthma. To ensure that inflammation is suppressed whilst using the lowest possible dose, a sensitive and specific method for assessing airway inflammation is needed. METHODS The usefulness of exhaled nitric oxide (NO), sputum eosinophils, and methacholine airway responsiveness (PC20) for monitori...
متن کاملEVect of diVering doses of inhaled budesonide on markers of airway inflammation in patients with mild asthma
Background—It is desirable to prescribe the minimal eVective dose of inhaled steroids to control asthma. To ensure that inflammation is suppressed whilst using the lowest possible dose, a sensitive and specific method for assessing airway inflammation is needed. Methods—The usefulness of exhaled nitric oxide (NO), sputum eosinophils, and methacholine airway responsiveness (PC20) for monitoring ...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2000
ISSN: 0903-1936,1399-3003
DOI: 10.1034/j.1399-3003.2000.16b08.x