Optical Mapping of cAMP Signaling at the Nanometer Scale

(Cell 182, 1519–1530.e1–e17; September 17, 2020) Our paper showed that spatiotemporal cAMP signaling is under the control of nanometer-sized domains shaped by phosphodiesterases, gating activation downstream effectors. Equations 1 and 2 were used to characterize spatial-temporal fluorescent diffusion. We have identified errors introduced into these equations when using Microsoft Word equation editor in preparation STAR Methods. π 4∗ omitted from denominator all terms 2, “t2+” was incorrectly included numerator exponential 2. The corrected appear below online. formulas computer codes analyze data correct, therefore none results conclusions are affected. apologize for any confusion may caused.G(x,t)=γπ⋅N⋅(4⋅D⋅t+σ02)e−((x−x0)2(4⋅D⋅t+σ02))(Equation 1) G(x,t)=γπ⋅N1⋅(4⋅D1⋅t+σ02)e−((x−x0)2(4⋅D1⋅t+σ02))+γπ⋅N2⋅(4⋅D2⋅t+σ02)e−((x−x0)2(4⋅D2⋅t+σ02))(Equation 2) Optical Mapping Signaling at Nanometer ScaleBock et al.CellAugust 25, 2020In BriefMapping dynamics concentrations live cells reveals how maintaining low levels free second messengers enables formation compartments. Full-Text PDF Open Archive