Optic nerve oxygen tension: effects of intraocular pressure and dorzolamide
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چکیده
منابع مشابه
Optic nerve oxygen tension: effects of intraocular pressure and dorzolamide.
AIM To investigate the influence of acute changes in intraocular pressure on the oxygen tension in the vicinity of the optic nerve head under control conditions and after intravenous administration of 500 mg of the carbonic anhydrase inhibitor dorzolamide. METHODS Domestic pigs were used as experimental animals. Oxygen tension was measured by means of a polarographic electrode in the vitreous...
متن کاملOptic nerve oxygen tension: the effects of timolol and dorzolamide.
BACKGROUND/AIMS The authors have previously reported that carbonic anhydrase inhibitors such as acetazolamide and dorzolamide raise optic nerve oxygen tension (ONPO(2)) in pigs. The purpose of the present study was to investigate whether timolol, which belongs to another group of glaucoma drugs called beta blockers, has a similar effect. In addition, the effect of dorzolamide and timolol in com...
متن کاملSCIENTIFIC REPORT Optic nerve oxygen tension: the effects of timolol and dorzolamide
Background/aims: The authors have previously reported that carbonic anhydrase inhibitors such as acetazolamide and dorzolamide raise optic nerve oxygen tension (ONPO2) in pigs. The purpose of the present study was to investigate whether timolol, which belongs to another group of glaucoma drugs called b blockers, has a similar effect. In addition, the effect of dorzolamide and timolol in combina...
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Base-line intraocular pressure was similar in the rabbit eye ivith a transected optic nerve and the opposite eye subjected to a sham operation. Hyperosmotic oral ethanol, at doses of 1.5 to 2.0 ml. per kilogram, lowered intraoctdar pressure significantly less in eyes with transected optic nerves than in their fellow eyes with intact optic nerves. Smaller doses of ethanol (0.75 ml. per kilogram)...
متن کاملDorzolamide increases retinal oxygen tension after branch retinal vein occlusion.
PURPOSE To study the effect of dorzolamide on the preretinal oxygen tension (RPO(2)) in retinal areas affected by experimental branch retinal vein occlusion (BRVO) in pigs. METHODS Experimental BRVO was induced by diathermy close to the optic disc. RPO(2) was measured with an oxygen-sensitive electrode 0.5 mm above the BRVO-affected area, which was compared to the retinal areas not affected b...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 2000
ISSN: 0007-1161
DOI: 10.1136/bjo.84.9.1045