Opioid receptors: toward separation of analgesic from undesirable effects
نویسندگان
چکیده
منابع مشابه
Adverse effects of opioid analgesic drugs.
Opioids were available in clinical practice since before the birth of modern anaesthesia--Setürner isolated morphine in 1806. They have a record of safety which is reflected in their high therapeutic ratios, especially the synthetic opioids introduced recently (table III). The most serious immediate adverse effect, respiratory depression, is a predictable effect related closely to analgesia. It...
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Editor’s Note: This editorial by Dr. Peggy Compton, and the three papers in this issue by Drs. Webster, Fishbain, Zacny, and their colleagues, initiate the Opioids, Substance Abuse & Addiction Section of Pain Medicine. Under the leadership of section co-editors Steve Passik, PhD, and Lynn Webster, MD, PhD, and their distinguished colleagues, this section will inform our readership about this cr...
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Since the first cases of severe and fatal liver damage were reported in 1966,1,2 overdose of paracetamol has become the cause of 100–200 deaths in the UK each year.3 Paracetamol toxicity remains the leading cause of fulminant hepatic failure in the UK and is a common reason for liver transplantation.4,5 Knowledge of the toxic mechanism (Fig 1) has led to effective antidotes which provide substr...
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Copyright © 2012 Massachusetts Medical Society. Opioid analgesic overdose is a preventable and potentially lethal condition that results from prescribing practices, inadequate understanding on the patient’s part of the risks of medication misuse, errors in drug administration, and pharmaceutical abuse.1,2 Three features are key to an understanding of opioid analgesic toxicity. First, opioid ana...
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Introduction: Melissa Officinalis (MO) overgrows in different parts of Iran. In previous studies, ethanol extract of aerial parts (leaf & stem) of MO showed anti-nconvulsant and sedative effects in rats. This study was designed to evaluate anti-nociceptive effects in different doses of aqueous decoction extracts of MO and the role of opioid receptors in rats. Methods: In this experimental stud...
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ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2013
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2013.03.003