Opioid-induced bowel dysfunction: prevalence, pathophysiology and burden
نویسندگان
چکیده
منابع مشابه
Opioid-induced bowel dysfunction: prevalence, pathophysiology and burden
As a result of the undesired action of opioids on the gastrointestinal (GI) tract, patients receiving opioid medication for chronic pain often experience opioid-induced bowel dysfunction (OBD), the most common and debilitating symptom of which is constipation. Based on clinical experience and a comprehensive MEDLINE literature review, this paper provides the primary care physician with an overv...
متن کاملa review of the clinical manifestations, pathophysiology and management of opioid bowel dysfunction and narcotic bowel syndrome
opioids are widely used for the treatment of malignant and non-malignant pains. these medications are accompanied by adverse effects, in particular gastrointestinal symptoms known as opioid bowel dysfunction (obd). the most common symptom of obd is refractory constipation that is usually stable regardless of the use of laxatives. narcotic bowel syndrome (nbs) is a subset of obd described as amb...
متن کاملDyspepsia and Opioid–Induced Bowel Dysfunction: The Role of Opioid Receptor Antagonists
Opioid analgesics are commonly and in most cases effectively used to manage chronic pain of moderate to severe intensity. Apart from analgesia, opioids exert numerous adverse ef‐ fects, several of which impact the gastrointestinal (GI) tract. The chronic use of opioid anal‐ gesics in fact is commonly associated with adverse effects on the gastrointestinal tract. [1] Opioid–induced bowel dysfunc...
متن کاملA Review of the Clinical Manifestations, Pathophysiology and Management of Opioid Bowel Dysfunction and Narcotic Bowel Syndrome
Opioids are widely used for the treatment of malignant and non-malignant pains. These medications are accompanied by adverse effects, in particular gastrointestinal symptoms known as opioid bowel dysfunction (OBD). The most common symptom of OBD is refractory constipation that is usually stable regardless of the use of laxatives. Narcotic bowel syndrome (NBS) is a subset of OBD described as amb...
متن کامل[Opioid-induced hyperalgesia. Pathophysiology and clinical relevance].
Opioids are the drugs of choice for the treatment of moderate to severe acute and chronic pain. However, clinical evidence suggests that opioids can elicit increased sensitivity to noxious stimuli suggesting that administration of opioids can activate both pain inhibitory and pain facilitatory systems. Acute receptor desensitization via uncoupling of the receptor from G-proteins, up-regulation ...
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ژورنال
عنوان ژورنال: International Journal of Clinical Practice
سال: 2007
ISSN: 1368-5031
DOI: 10.1111/j.1742-1241.2007.01415.x