Opioid-Induced Bowel Dysfunction in Patients Undergoing Spine Surgery: Comparison of Oxycodone and Oxycodone-Naloxone Treatment
نویسندگان
چکیده
منابع مشابه
Opioid-Induced Bowel Dysfunction in Patients Undergoing Spine Surgery: Comparison of Oxycodone and Oxycodone-Naloxone Treatment
INTRODUCTION Opioids are needed for postoperative pain in spine surgery patients, but opioid-induced constipation is a harmful adverse event. The aim of this clinical trial was to compare the use of a controlled-release oxycodone-naloxone combination product with oxycodone controlled-release tablets in these patients. The main outcome measure was the prevalence of constipation at 7 days postope...
متن کاملOxycodone and Naloxone Combination: A 12-Week Follow-up in 20 Patients Shows Effective Analgesia Without Opioid-Induced Bowel Dysfunction
INTRODUCTION Opioid analgesics are widely regarded to be highly effective but are equally known for their side effects on the bowel. A new combination of the opioid analgesic oxycodone and naloxone has been developed to combat opioid-induced bowel dysfunction (OIBD) whilst still being effective as an analgesic. The aim of this observational study was to assess the analgesic efficacy of this new...
متن کاملOxycodone/naloxone as a therapeutic option in a patient with chronic pain and opioid-induced bowel dysfunction
Cancer-induced pain is a complex issue of utmost importance in everyday clinical practice. Published data show that the majority of patients with advanced or disseminated cancer and between 27% and 60% of ambulatory cancer patients in various stages of the disease may suffer from moderate or severe pain (VAS 5–10) [1, 2]. However, it has been demonstrated that up to 82% of patients with cancer-...
متن کاملRole of oxycodone and oxycodone/naloxone in cancer pain management.
Oxycodone is a valued opioid analgesic, which may be administered either as the first strong opioid or when other strong opioids are ineffective. In case of insufficient analgesia and/or intense adverse effects such as sedation, hallucinations and nausea/vomiting a switch from another opioid to oxycodone might be beneficial. Oxycodone is administered to opioid-naive patients with severe pain an...
متن کاملEfficacy and tolerability of oral oxycodone and oxycodone/naloxone combination in opioid-naïve cancer patients: a propensity analysis
BACKGROUND World Health Organization step III opioids are required to relieve moderate-to-severe cancer pain; constipation is one of the most frequent opioid-induced side effects. A fixed combination, prolonged-release oxycodone/naloxone (OXN), was developed with the aim of reducing opioid-related gastrointestinal side effects. The objective of this study was to compare the efficacy and safety ...
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ژورنال
عنوان ژورنال: Advances in Therapy
سال: 2016
ISSN: 0741-238X,1865-8652
DOI: 10.1007/s12325-016-0456-9