Opiate-induced changes in brain adenosine levels and narcotic drug responses
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چکیده
منابع مشابه
Changes in Catecholamines and Acetylcholinesterase Levels of Crebellum, Mid-brain and Brain Cortex in Chromium Treated Rats
The short and long term effects of chromium toxicity on brain catecholamines and acetylcholinesterase levels were investigated. Rats were injected daily with varying amounts of chromium. The short term (2 h) administration of chromium (8 mmol/kg) reduced catecholamines level of cerebellum, mid-brain and brain-cortex by 22.8, 19.4 and 21.2% respectively. Acetylcholinesterase activity was also re...
متن کاملChanges in Catecholamines and Acetylcholinesterase Levels of Crebellum, Mid-brain and Brain Cortex in Chromium Treated Rats
The short and long term effects of chromium toxicity on brain catecholamines and acetylcholinesterase levels were investigated. Rats were injected daily with varying amounts of chromium. The short term (2 h) administration of chromium (8 mmol/kg) reduced catecholamines level of cerebellum, mid-brain and brain-cortex by 22.8, 19.4 and 21.2% respectively. Acetylcholinesterase activity was also re...
متن کاملOpioid-induced decreases in rat brain adenosine levels are reversed by inhibiting adenosine deaminase.
BACKGROUND Opioids disrupt sleep and adenosine promotes sleep, but no studies have characterized the effects of opioids on adenosine levels in brain regions known to regulate states of arousal. Delivering opioids to the pontine reticular formation (PRF) and substantia innominata (SI) region of the basal forebrain disrupts sleep. In contrast, administering adenosine agonists to the PRF or SI inc...
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Opiates and opioids are naturally occurring or synthesized derivatives of opium commonly known as “narcotics.” Short-acting narcotics often are used for the acute treatment of migraine headache that is moderate to severe in intensity. Orally self-administered narcotics that are commonly prescribed include codeine (typically prescribed with acetaminophen; eg, Tylenol #3), hydrocodone (typically ...
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A study was performed to elucidate opiate-induced metabolic changes in murine brain. The EI MS, EI MS/MS, and PCI capabilities of the Agilent 7200 Series GC/Q-TOF MS, in combination with Agilent MassHunter Software tools, enabled a very flexible and comprehensive workflow for identifying metabolomic differences. The workflow was used to distinguish between morphine-sensitive and resistant murin...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2013
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2012.10.031