Opiate dependence and withdrawal: role of oxidative stress in opiate regulations
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چکیده
منابع مشابه
Role of Brain Stress System in Opiate Dependence and Withdrawal: Neuronal-, Cellular- and Molecular Mechanisms
Stress and stress-associated high levels of glucocorticoid hormones are well-known risk factors in the development of drug addiction and vulnerability to relapse (Koob & Kreek, 2007; Koob, 2008). Human studies indicated that addicts often use drugs to relive their stress and anxiety. Moreover, psychological stress is known to increase vulnerability to addiction. This „self treatment” may initia...
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Withdrawal from opiates, such as heroin or oral narcotics, is characterized by a host of aversive physical and emotional symptoms. High rates of relapse and limited treatment success rates for opiate addiction have prompted a search for new approaches. For many opiate addicts, achieving abstinence may be further complicated by poly-drug use and co-morbid mental disorders. Research over the past...
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The abstinence syndrome which follows withdrawal of opiates is the prototype of drug withdrawal reaction and is one of the several factors promoting addiction. Although management of this syndrome is but a small part of treatment of an addict, it is nonetheless an important one. Recent studies have shown that a single dose of Clonidine hydrochloi ide (ARKAMIN) relieves signs and symptoms of opi...
متن کاملNeonatal opiate withdrawal.
With increasing maternal drug abuse, the paediatrician must be ever alert to the possibility that symptoms observed in a young baby might be the consequence of drug withdrawal. The absence of a positive maternal drug history in no way negates this diagnostic possibility. Although opiate withrawal is the subject of this paper, combinations of drugs are commonly involved and there may sometimes b...
متن کاملStress evoked by opiate withdrawal facilitates hippocampal LTP in vivo.
Stress impairs hippocampal long-term potentiation (LTP), but it is unknown whether the stress evoked by opiate withdrawal has the same effect. Here the authors report that opiate withdrawal for 4 days does not influence basal synaptic transmission, but results in a greatly increased LTP in hippocampal CA1 area in anesthetized rats. Elevated-platform stress enabled a large LTP in rats withdrawn ...
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ژورنال
عنوان ژورنال: Bangladesh Journal of Medical Science
سال: 2015
ISSN: 2076-0299,2223-4721
DOI: 10.3329/bjms.v14i2.22784