Ophelia Unbound in Asian Performances

The Ophelia Traceability Layer

Assessing the impact of change on a software development project is a critical management activity. Traceability affords us opportunities to manage the change process through notification and synchronisation mechanisms. We present an architecture, developed as part of the EU funded Ophelia project, that supports traceability across all project artefacts.

Ophelia syndrome with metabotropic glutamate receptor 5 antibodies in CSF.

Exocytosis unbound.

The accepted theory of vesicular release of neurotransmitter posits that only a single vesicle per synapse can fuse with the membrane following action potential invasion, and this exocytotic event is limited to the ultrastructurally defined presynaptic active zone. Neither of these dictums is universally true. At certain synapses, more than a single vesicle can be released per action potential,...

Ophelia syndrome: Hodgkin lymphoma with limbic encephalitis.

BACKGROUND Limbic encephalitis, an immune-mediated encephalitis, results from inflammation in the medial temporal lobes. The paraneoplastic form is rare in pediatric population, and frequently precedes tumor diagnosis. CASE CHARACTERISTICS A 9-year-old boy receiving chemotherapy for Hodgkin lymphoma, developed headache, temporal lobe seizures, anxiety, hallucinations, short-term memory loss a...

Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome.

OBJECTIVE To report the metabotropic glutamate receptor 5 (mGluR5) as the autoantigen of antibodies from 2 patients with Hodgkin lymphoma (HL) and limbic encephalopathy (Ophelia syndrome). METHODS Immunohistochemistry with brain tissue and cultures of rat hippocampal neurons were used to demonstrate antibodies. Immunoprecipitation, mass spectrometry, and mGluR5-null mice served to identify th...