OpenCYP: An open source database exploring human variability in activities and frequencies of polymophisms for major cytochrome P-450 isoforms across world populations

The open source database “OpenCYP database” has been developed based on the results of extensive literature searches from peer-reviewed literature. OpenCYP provides data human variability baseline activities and polymophism frequencies for selected cytochrome P-450 isoforms (CYP1A2, CYP2A6, CYP2D6, CYP3A4/3A5 CYP3A7) in healthy adult populations world populations. CYP enzymatic were generally expressed as metabolic ratio (MR) between an unchanged probe drug its metabolite(s) urine or plasma measured adults. Data other age groups very limited fragmented, constituting important gap. Quantitative comparisons often hampered by different experimental conditions used. However, was quite CYP1A2, using caffeine a substrate, with symmetrical distribution activity values. For CYP3A4, dependent substrate itself low when considering dextromethorphan/demethilathed metabolite MR used large urinary 6β-hydroxycortisol/cortisol largest shown CYP2D6 activity, after oral dosing dextromethorphan, which genetic polymorphisms are well characterised constitute significant variability. It is foreseen that can contribute to promising tools support further development QIVIVE PBK models risk assessment chemicals particularly combined information isoform-specific content cells proteomic approaches.