Open science datasets from PREVENT-AD, a longitudinal cohort of pre-symptomatic Alzheimer’s disease

• PREVENT-AD is openly releasing datasets to the neuroscience community. a longitudinal study of older adults at-risk Alzheimer disease. Data include imaging, genetics, fluid biochemistry, neurosensory, cognition and more. collection methods data sharing plans for open science are described. To move Disease (AD) research forward it essential collect from large cohorts, but also make such available global We describe creation an dataset (PResymptomatic EValuation Experimental or Novel Treatments AD) cohort, composed cognitively unimpaired individuals with parental multiple-sibling history AD. From 2011 2017, 386 participants were enrolled (mean age 63 years old ± 5) sustained investigation among whom 349 have retrospectively agreed share their openly. Repositories findable through unified interface Canadian Open Neuroscience Platform contain up five imaging data, cerebral neurosensory capacities, cognitive, genetic, medical information. Imaging can be accessed at https://openpreventad.loris.ca while most other information, sensitive by nature, accessible qualified researchers https://registeredpreventad.loris.ca . In addition being living resource continued acquisition, offers opportunities facilitate understanding AD pathogenesis.