OP13.03: Maternal determinants of congenital Zika virus infection

Zika Virus Infection after Returning from Thailand

Evidence for Congenital Zika Virus Infection From Neutralizing Antibody Titers in Maternal Sera, Northeastern Brazil

Reliable diagnosis of congenital Zika virus (ZIKV) infection is challenging. Here, we assessed ZIKV-specific neutralizing antibodies in 28 mothers of children with microcephaly (cases) and 122 controls from northeastern Brazil using plaque reduction neutralization tests. ZIKV-specific antibody titers were significantly higher in cases than in controls (t test, P < .0001). We identified a putati...

Adulthood Sequelae of Congenital Zika Virus Infection in Mice

a Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA b Department of Phamarcology & Toxicology, University of Texas Medical Branch, Galveston, TX, USA c Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, USA d Sealy Center for Vaccine Development, University of Texas Medical Branch, G...

Confirmed case of Zika virus congenital infection, Spain, March 2016.

We describe Zika virus (ZIKV) vertical transmission in an imported case in Spain, in a 17-week pregnant woman. ZIKV IgG, IgM and RNA were detected in serum in week 17. At 19 weeks, ultrasound scan revealed fetal malformations and ZIKV was detected in the amniotic fluid. Pregnancy was terminated at week 21; autopsy of the fetus revealed bilateral hydrocephalus, brain microcalcifications and arth...

Prolonged Shedding of Zika Virus Associated with Congenital Infection.

Panel A shows the clinical timeline of pregnancy and delivery events and examinations, indicating the results of testing of serum, urine, and saliva obtained from the newborn for Zika virus (ZIKV) on quantitative real-time polymerase-chain-reaction (qRT-PCR) assay. Also outlined are the main ZIKV-related events, as shown in color-coded text with respect to the illnesses of the mother and the fa...