OP0104 DIFFERENCES IN LOW-DENSITY LIPOPROTEIN (LDL) PARTICLE COMPOSITION AND OXIDATION MAY UNDERLIE THE PARADOXICAL ASSOCIATION OF LOW LDL WITH HIGHER CORONARY ATHEROSCLEROSIS BURDEN IN RHEUMATOID ARTHRITIS

Background: The association between cholesterol and cardiovascular disease (CVD) risk is attenuated in Rheumatoid arthritis (RA). In fact, RA patients the lowest low-density lipoprotein (LDL) group (<70mg/dl) may experience unexpectedly high CVD risk. Objectives: We here explored whether with LDL<70mg/dl (Group 1) had higher coronary atherosclerosis burden compared to other LDL groups 2: 70≤LDL≤130 Group 3: LDL>130), as a reason for this further evaluated low 1 associated differences inflammation, particle composition or oxidation. Methods: One hundred fifty without symptoms history of underwent evaluation computed tomography angiography. Coronary artery calcium (CAC), number segments plaque (segment involvement score), stenotic severity stenosis extensive (>4 plaque) obstructive (>50% stenosis) were assessed. Lipoprotein classes subclasses directly measured. Oxidized (oxLDL) was measured monoclonal antibody E06. Chemiluminescence Elisa quantified IgG IgM antibodies oxLDL (anti-oxLDL) apoB100 immune complexes (IC). Proinflammatory cytokines Erenna Immunoassay. Robust linear logistic regression models- adjusted Framingham D’Agostino score, obesity, activity, bDMARD statin treatment- associations outcomes. Similar models subclasses, oxLDL, anti-oxLDL, anti-ApoB100 IC, across groups. Results: (Figure 1A) 2.8 times greater (adjusted OR 2.82 [95% CI 1.12-7.17], P = 0.031) LDL>70 Among naïve patients, those LDL<70 also (log-transformed mean 2.55 2.34-2.77] versus 2.27 2.19-2.36], 0.018 LDL>70). Notably, anti-oxLDL IC levels 1B). subclass relative content differed 1C). Lp(a) particles 16.04% 11.75-20.33], 10.48% 8.20-12.75] 2, 0.026 7.41% 0.77-14.04] 3, 0.033). strongly overall ( r 0.83, < 0.0001). This stronger others 0.005, Figure 1D). No CRP, TNF-α, IL-17A, IL-17F seen However, IL-6 1.98 1.64- 2.32] 1.57 1.45-1.70], 0.028 2 1.32 0.84-1.80], 0.031 3). both 0.015) anti-apoB100 0.016). Log-transformed log-transformed CAC B 0.41 0.01-0.81], 0.049). Conclusion: mg/dl burden. Low circulating that reflect oxidation; mostly linked larger its significantly oxidation potential group. OxLDL recognition Ab group, which elaboration Disclosure Interests: George Karpouzas Speakers bureau: Sanofi/ Genzyme/ Regeneron, Consultant of: Grant/research support from: Pfizer, Sarah Ormseth: None declared, Elizabeth Hernandez: Matthew Budoff Pfizer