Ontogeny of human mucosal-associated invariant T cells and related T cell subsets
نویسندگان
چکیده
منابع مشابه
Human Leptin Hormone Affects TNF-α Production in Mucosal-associated Invariant T Cells
Background and Aims: Mucosal-associated invariant T (MAIT) cells are striking lymphocyte population in the blood and their importance in immune responses is growing fast. The current study was conducted to evaluate leptin hormone effects on MAIT cell functions. Materials and Methods: Five healthy male donors in ages of 22-30 years were selected and peripheral blood mononuclear cells (PBMCs) ...
متن کاملmucosal-associated invariant T cells
© 2008 Huang et al. The Rockefeller University Press $30.00 J. Exp. Med. Vol. 205 No. 5 1201-1211 www.jem.org/cgi/doi/ 1201 10.1084/jem.20072579 Mucosal-associated invariant T cells (MAITs) are a unique “ innate ” T cell population that expresses an invariant mV 19 TCR in mice and the homologous hV 7.2 in humans ( 1 ). With the exception of preferential localization in the intestine, MAIT cell...
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Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role. High frequency Mtb-reactive CD8+ T cells are present in both Mtb-infected and uninfected humans. We show by limiting dilution analysis that nonclassically restricted CD8+ T cells are universally present, but predominate in Mtb-uninfected individuals. Interestingly, th...
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Coeliac disease is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals. The only current therapy is a lifelong gluten free diet. While much work has focused on the gliadin-specific adaptive immune response in coeliac disease, little is understood about the involvement of the innate immune system. Here we used m...
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A common finding when measuring T cell immunity to enteric bacterial vaccines in humans is the presence of background responses among individuals before immunization. Yet the nature of these background responses remains largely unknown. Recent findings show the presence in uninfected individuals of mucosal associated invariant T (MAIT) cells that mount broad spectrum immune responses against a ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2018
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.20171739