On?Surface Decarboxylation Coupling Facilitated by Lock?to?Unlock Variation of Molecules upon the Reaction

On-surface synthesis (OSS) involving relatively high energy barriers remains challenging due to a typical dilemma: firm molecular anchor is required prevent desorption upon the reaction, whereas sufficient lateral mobility crucial for subsequent coupling and assembly. By locking precursors on substrate then unlocking them during we present strategy address this challenge. High-yield based well-defined decarboxylation, intermediate transition, hexamerization demonstrated, resulting in an extended ordered network exclusively composed of newly synthesized macrocyclic compound. Thanks steric hindrance its maleimide group, attain preferential selection coupling. This work unlocks promising path enrich reaction types improve selectivity hence structual homogeneity final product OSS.