One percent of human circulating B lymphocytes are capable of producing the natural anti-Gal antibody
نویسندگان
چکیده
منابع مشابه
One percent of human circulating B lymphocytes are capable of producing the natural anti-Gal antibody.
The natural anti-Gal antibody constitutes 1% of circulating IgG in humans and interacts specifically with the carbohydrate epitope Gal alpha 1-3Gal beta 1-4GlcNAc-R (the alpha-galactosyl epitope). In view of the unusually large amounts of this antibody in the serum, it was of interest to determine the proportion of circulating B lymphocytes capable of synthesizing anti-Gal. For this purpose, bl...
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B-1b cells produce IgM natural antibodies against 1-3Gal 1-4GlcNAc ( Gal). These can be tolerized by nonmyeloablative induction of mixed chimerism using Galpositive ( Gal ) donor marrow. We assessed the role of CR1/2 in this model for induction of tolerance of B-1b cells. Mixed hematopoietic chimerism was induced in 1-3galactosyltransferase (GalT / ) and GalT / Cr2 / mice with Gal BALB/c marrow...
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This work is licensed under a Creative Commons Attribution 3.0 License. Galili, Uri, "Acceleration of wound healing by alpha-gal nanoparticles interacting with the natural anti-Gal antibody" (2015).
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متن کاملThe human natural anti-Gal IgG. III. The subtlety of immune tolerance in man as demonstrated by crossreactivity between natural anti-Gal and anti-B antibodies
A well-defined antigen/antibody system was used to evaluate the effect of immune tolerance on the spectrum of specificities of natural antibodies. The antibody used in this study, anti-Gal, is a naturally occurring, polyclonal IgG that constitutes 1% of the circulating IgG in humans. We have previously shown that anti-Gal, purified from AB sera, specifically interacts with glycosphingolipids be...
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ژورنال
عنوان ژورنال: Blood
سال: 1993
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v82.8.2485.2485