Onco‐miR‐155 targets SHIP1 to promote TNFα‐dependent growth of B cell lymphomas
نویسندگان
چکیده
منابع مشابه
Onco-miR-155 targets SHIP1 to promote TNFα-dependent growth of B cell lymphomas
Non-coding microRNAs (miRs) are a vital component of post-transcriptional modulation of protein expression and, like coding mRNAs harbour oncogenic properties. However, the mechanisms governing miR expression and the identity of the affected transcripts remain poorly understood. Here we identify the inositol phosphatase SHIP1 as a bonafide target of the oncogenic miR-155. We demonstrate that in...
متن کاملOnco-miR-155 targets SHIP1 to promote TNFa-dependent growth of B cell lymphomas
(1) Section of Molecular Biology, Division of Biological S California San Diego, La Jolla, CA, USA. (2) Burnham Institute for Medical Research, La Jolla, CA (3) Department of Hematology, Copenhagen University H Denmark. (4) Department of Pathology, Copenhagen University H Denmark. (5) Moores Cancer Center, University of California San D *Corresponding author: Tel: þ1 858 8221108; Fax: þ E-mail:...
متن کاملA Practical Guide to Differential Diagnosis of Small B Cell Lymphomas
Correct diagnosis and classification of lymphoid neoplasms depends on the integration of morphologic, immunophenotypic and molecular genetic features. The mature small B cell lymphomas despite their overlapping histomorphologies, have different clinical behavior and treatment. In this review, differentia...
متن کاملA systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomas
The computational identification of oncogenic lesions is still a key open problem in cancer biology. Although several methods have been proposed, they fail to model how such events are mediated by the network of molecular interactions in the cell. In this paper, we introduce a systems biology approach, based on the analysis of molecular interactions that become dysregulated in specific tumor ph...
متن کاملCutaneous B-cell Lymphomas
Clinical features and history Cutaneous B-cell lymphomas usually present as one or more erythematous papules or nodules that may coalesce to form plaques. They are usually localized tumors effecting one cutaneous region and rarely ulcerate. There is some regional predilection for various sub-types of tumors; follicle center lymphoma more commonly arises on the scalp, marginal zone B-cell lympho...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: EMBO Molecular Medicine
سال: 2009
ISSN: 1757-4676,1757-4684
DOI: 10.1002/emmm.200900028