Oncogenes in high grade serous adenocarcinoma of the ovary
نویسندگان
چکیده
منابع مشابه
Expression profiling of serous low malignant potential, low-grade, and high-grade tumors of the ovary.
Papillary serous low malignant potential (LMP) tumors are characterized by malignant features and metastatic potential yet display a benign clinical course. The role of LMP tumors in the development of invasive epithelial cancer of the ovary is not clearly defined. The aim of this study is to determine the relationships among LMP tumors and invasive ovarian cancers and identify genes contributi...
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BACKGROUND Epithelial ovarian cancer is the most lethal of all gynecologic malignancies, and high grade serous ovarian cancer (HGSC) is the most common subtype of ovarian cancer. The objective of this study was to determine the frequency and types of point somatic mutations in HGSC using a mutation detection protocol called OncoMap that employs mass spectrometric-based genotyping technology. ...
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OBJECTIVE To evaluate the CT features of pathologically proven low grade serous carcinoma (LGSC) of the ovary. METHODS Patients with a pathologic diagnosis of LGSC and CT prior to oophorectomy were retrospectively identified. The CT scans in 14 patients were available and were analyzed for an adnexal mass, peritoneal mass and ascites. The adnexal mass was characterized as complex primarily cy...
متن کاملDriver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary
Numerous studies have tested the association between TP53 mutations in ovarian cancer and prognosis but these have been consistently confounded by limitations in study design, methodology, and/or heterogeneity in the sample cohort. High-grade serous (HGS) carcinoma is the most clinically important histological subtype of ovarian cancer. As these tumours may arise from the ovary, Fallopian tube ...
متن کاملMRI for differentiating ovarian endometrioid adenocarcinoma from high-grade serous adenocarcinoma
PURPOSE To investigate magnetic resonance imaging (MRI) features for differentiating ovarian endometrioid adenocarcinoma (OEC) from high-grade serous adenocarcinoma (HGSC). MATERIALS AND METHODS Twenty-three patients with 25 OECs and 93 patients with 139 HGSCs confirmed by surgery and pathology underwent conventional MRI and diffusion-weighted imaging (DWI). The MRI features of the tumors, in...
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ژورنال
عنوان ژورنال: Genes & Cancer
سال: 2020
ISSN: 1947-6027
DOI: 10.18632/genesandcancer.206