Oncofetal Gene SALL4 in Aggressive Hepatocellular Carcinoma

Oncofetal gene SALL4 in aggressive hepatocellular carcinoma.

BACKGROUND Hepatocellular carcinoma is the third leading cause of cancer-related deaths worldwide. In the heterogeneous group of hepatocellular carcinomas, those with characteristics of embryonic stem-cell and progenitor-cell gene expression are associated with the worst prognosis. The oncofetal gene SALL4, a marker of a subtype of hepatocellular carcinoma with progenitor-like features, is asso...

Oncofetal Gene SALL4 in Aggressive Hepatocellular Carcinoma

Kol Jia Yong, B.Sc., Chong Gao, M.D., Ph.D., Joline S.J. Lim, M.B., B.S., Benedict Yan, M.B., B.S., Henry Yang, Ph.D., Todor Dimitrov, Ph.D., Akira Kawasaki, M.D., Ph.D., Chee Wee Ong, M.Sc., Kwong-Fai Wong, Ph.D., Sanghoon Lee, Ph.D., Sharada Ravikumar, M.D., Ph.D., Supriya Srivastava, M.D., Xi Tian, B.S., Ronnie T. Poon, M.B., B.S., Ph.D., Sheung Tat Fan, M.D., D.Sc., John M. Luk, D.Med.Sc., ...

Clinicopathologic characteristics of SALL4-immunopositive hepatocellular carcinoma

The aim of this study was to investigate the clinicopathologic characteristics of sal-like protein 4 (SALL4)-immunopositive hepatocellular carcinoma (HCC). Solitary HCCs that were surgically treated at the University of Tokyo Hospital between 2000 and 2008 were the subject of this study. Diffuse, non-punctate nuclear immunoreactivity to SALL4 was observed in 47 of 337 HCCs (13.9%). Compared to ...

Hepatocellular Carcinoma in Sheep

Oncofetal gene SALL4 and prognosis in cancer: A systematic review with meta-analysis

The Spalt-Like Transcription Factor 4 (SALL4) oncogene plays a central function in embryo-fetal development and is absent in differentiated tissues. Evidence suggests that it can be reactivated in several cancers worsening the prognosis. We aimed at investigating the risk associated with SALL4 reactivation for all-cause mortality and recurrence in cancer using the current literature. A PubMed a...