Once anomaly, twice coincidence, thrice…

Once bitten, twice shy.

Compliance with Once-Daily versus Twice or Thrice-Daily Administration of Antibiotic Regimens: A Meta-Analysis of Randomized Controlled Trials

OBJECTIVE To investigate whether compliance of patients to antibiotic treatment is better when antibiotics are administered once than multiple times daily. METHODS We performed a systematic search in PubMed and Scopus databases. Only randomized controlled trials were considered eligible for inclusion. Compliance to antibiotic treatment was the outcome of the meta-analysis. RESULTS Twenty-si...

Once-Weekly Exenatide Versus Once- or Twice-Daily Insulin Detemir

OBJECTIVE This multicenter, open-label, parallel-arm study compared the efficacy and safety of exenatide once weekly (EQW) with titrated insulin detemir in patients with type 2 diabetes inadequately controlled with metformin (with or without sulfonylureas). RESEARCH DESIGN AND METHODS Patients were randomized to EQW (2 mg) or detemir (once or twice daily, titrated to achieve fasting plasma gl...

Lightning strikes twice: intron-intein coincidence.

‘‘Multiple introns, and the prospect that these occur within several genes in the same metabolic pathway, suggest a regulatory role for splicing . . . ’’ (1). That statement was made more than a decade ago by our colleagues and ourselves in reference to the phage T4 group I introns, all three of which reside in genes involved in nucleotide metabolism. The intervening years were distinguished by...

Once versus thrice daily colistin in critically ill patients with multi-drug resistant infections

Objectives: The aim of this study was to evaluate the procalcitonin (PCT) changes in two different high-dose colistin regimens in the treatment of multi-drug resistant MDR gram negative infections in ICU patients. Method: This is a prospective study of adult ICU patients with bacteremia and ventilator associated pneumonia (VAP) caused by MDR gram negative pathogens. Patients were assigned to t...