On the Thrombin-Fibrinogen Reaction in Different Species.
نویسندگان
چکیده
منابع مشابه
Species differences in the interaction of thrombin and fibrinogen.
When thrombin from the blood plasma of one class of vert,ebrates is allowed to react with fibrinogen from the plasma of a vertebrate from another class, the ensuing clotting times are invariably longer than would be the case if the thrombin and fibrinogen had both been from closely related animals (1). Furthermore, the degree of interference imposed by this “species specificity” is apparently n...
متن کاملVariations in the reaction between thrombin and fibrinogen and their effect on the prothrombin time.
The appearance of fibrin provides the end-point in every clotting test, and the duration of the thrombin-fibrinogen reaction is thus a component of any measurement of clottinig time' While many tests are designed to study the early stages of clotting, in interpreting the results it is necessary to consider to what extent the observed differences may be due simply to differences in the " indicat...
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THE solutions of fibrinogen, thrombin and sodium chloride employed in these experiments contained about 0 5 % of tri-sodium citrate. As source of fibrinogen human plasma was ordinarily used, being prepared by mixing 12 cc. of blood, immediately after withdrawal from a vein of the forearm, with 1 cc. of 0-85 % sodium chloride solution to which 013 g. sodium citrate had been added. After centrifu...
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متن کاملThe fibrinogen sequences that interact with thrombin.
HE SERINE PROTEASE thrombin interacts with a T variety of substrates and as a consequence is involved in a number of physiologic processes. Fibrinogen is a particularly interesting substrate of thrombin for a number of reasons. First, thrombin cleaves not just one but four peptide bonds in fibrinogen, apparently in four successive steps. As a result ofthese proteolytic cleavages, the soluble fi...
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ژورنال
عنوان ژورنال: Acta Chemica Scandinavica
سال: 1965
ISSN: 0904-213X
DOI: 10.3891/acta.chem.scand.19-0751