On set‐based association tests: Insights from a regression using summary statistics
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چکیده
منابع مشابه
Polygenic scores using summary statistics via penalized regression
Polygenic scores (PGS) summarize the genetic contribution of a person’s genotype to a disease or phenotype. They are useful in a wide variety of analyses of genetic data. Many possible ways of calculating polygenic scores have been proposed, and recently there is much interest in methods that incorporate information available in published summary statistics. As there is no inherent information ...
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A Theoretical derivation of RSS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 A.1 Proofs of propositions in main text . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 A.1.1 Proof of Proposition 2.1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 A.1.2 Proof of Proposition 2.2 . . . . . . . . . . . . . . ....
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Bayesian methods for large-scale multiple regression provide attractive approaches to the analysis of genome-wide association studies (GWAS). For example, they can estimate heritability of complex traits, allowing for both polygenic and sparse models; and by incorporating external genomic data into the priors, they can increase power and yield new biological insights. However, these methods req...
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References Gleason, J. R. 1997. ip18: A command for randomly resampling a dataset. Stata Technical Bulletin 37: 17–22. Reprinted in Stata Technical Bulletin Reprints, vol. 7, pp. 77–83. ——. 1999. ip18.1: Update to resample. Stata Technical Bulletin 52: 9–10. Reprinted in Stata Technical Bulletin Reprints, vol. 9, p. 119. Weesie, J. 1997. dm46: Enhancement to the sample command. Stata Technical ...
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Genome-wide and, very soon, sequencing association studies, might yield multiple regions harbouring interesting association signals. Given that each region encompasses numerous variants in high linkage disequilibrium, it is not clear which are i) truly causal or ii) just reasonably close to the causal ones. Researchers proposed many methods to predict, albeit not test, the causal SNPs in a regi...
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ژورنال
عنوان ژورنال: Canadian Journal of Statistics
سال: 2020
ISSN: 0319-5724,1708-945X
DOI: 10.1002/cjs.11584