منابع مشابه
A physiological view and structures of mean residence times.
The author's previous theoretical study described the determination of a physiologically realistic structure of a mean residence time of an intravenously administered drug (Ďurišová 2012). This study continues previous work and the aim is to determine physiologically realistic structures of mean residence times of a drug administered either orally (MRTpo) or intramuscularly (MRTim). The determi...
متن کاملSimple Pharmacokinetic Model Based on Mean Residence Times to Predict Furosemide Exposure after Oral Doses
Oral bioavailability of furosemide is low (around 70%) even if a solution of 40 mg is given to healthy subjects. Sustained release formulations rendered even lower absorption of drug (one half of immediate release formulations). First pass metabolism in the stomach, slow dissolution of solid formulations in acidic media, and a narrow absorption window in the upper portion of the small intestine...
متن کاملMean first-passage and residence times of random walks on asymmetric disordered chains
The problems of the first-passage time (FPT) [1, 2] and the residence time (RT) [3] are very important issues in random walk theory. Moreover, several properties of diffusion and transport in disordered systems are based in this concepts. Here, we do not want to present a survey of the enormous literature in the field of mean firstpassage time (MFPT) and mean residence time (MRT) of random walk...
متن کاملTransient residence and exposure times
The residence time measures the time spent by a water parcel or a pollutant in a given water body and is therefore widely used in environmental studies. The adjoint method introduced by Delhez et al. (2004) to compute this diagnostic is revised here to take into account the effect of the initialization and of the boundary conditions. In addition to the equation for the mean residence time, it i...
متن کاملComputerized evaluation of mean residence times in multicompartmental linear system and pharmacokinetics
Deriving mean residence times (MRTs) is an important task both in pharmacokinetics and in multicompartmental linear systems. Taking as starting point the analysis of MRTs in open or closed (Garcia-Meseguer et al., Bull Math Biol 2003, 65, 279) multicompartmental linear systems, we implement a versatile software, using the Visual Basic 6.0 language for MS-Windows, that is easy to use and with a ...
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ژورنال
عنوان ژورنال: Mathematical Biosciences
سال: 1981
ISSN: 0025-5564
DOI: 10.1016/0025-5564(81)90106-1